diff --git a/changelog.d/10738.misc b/changelog.d/10738.misc
new file mode 100644
index 0000000000000000000000000000000000000000..cef54153dcfac04b15bb641068d88f009ed5b6ae
--- /dev/null
+++ b/changelog.d/10738.misc
@@ -0,0 +1 @@
+Additional error checking for the `preset` field when creating a room.
diff --git a/synapse/handlers/room.py b/synapse/handlers/room.py
index b33fe09f77eb480f42272838bf42822f394bde28..ed780bb41f8eb47d6c31b76bb6463d4370147d06 100644
--- a/synapse/handlers/room.py
+++ b/synapse/handlers/room.py
@@ -909,7 +909,12 @@ class RoomCreationHandler(BaseHandler):
             )
             return last_stream_id
 
-        config = self._presets_dict[preset_config]
+        try:
+            config = self._presets_dict[preset_config]
+        except KeyError:
+            raise SynapseError(
+                400, f"'{preset_config}' is not a valid preset", errcode=Codes.BAD_JSON
+            )
 
         creation_content.update({"creator": creator_id})
         await send(etype=EventTypes.Create, content=creation_content)